靶标:
MGLL
产品别名:
HU-K5; HUK5; MAGL; MGL; MGLL; monoglyceride lipase; monoglyceride lipase; monoglyceride lipase; lysophospholipase homolog; monoacylglycerol lipase; 单酰甘油脂肪酶; 单酰甘油脂肪酶(MGL);
背景信息:
This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.