靶标:
Cdca3
产品别名:
2410005A12Rik; C8; Grcc8; Tome-1; Cdca3; cell division cycle associated 3; cell division cycle associated 3; cell division cycle-associated protein 3; gene rich cluster, C8; gene-rich cluster protein C8; trigger of mitotic entry 1; trigger of mitotic entry protein 1; 细胞分裂周期相关蛋白3;
背景信息:
domain:The KEN box is required for the association with the APC/C-Cdh1 complex.,function:F-box-like protein which is required for entry into mitosis. Acts by participating to E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Ubiquitinated and degraded by the APC/C-Cdh1 complex.,subunit:Interacts with SKP1A. Part of a SCF (SKP1-cullin-F-box) protein ligase complex.,