靶标：
Jpt1
产品别名：
Hn1； Jpt1； Jupiter microtubule associated homolog 1； Jupiter microtubule associated homolog 1； jupiter microtubule associated homolog 1； hematological and neurological expressed 1 protein； hematological and neurological expressed sequence 1； 雄激素调节蛋白2；
背景信息：
Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation.
