靶标：
Reg3b
产品别名：
HIP； PAP1； Pap； REG-III； Reg3b； regenerating islet-derived 3 beta； regenerating islet-derived 3 beta； regenerating islet-derived protein 3-beta； REG-3-beta； RegIII (beta)； pancreatitis-associated protein 1； reg III-beta； regenerating islet-derived protein III-beta； 再生胰岛衍生蛋白3β(REG3b)； 胰岛β细胞生长因子Reg IIIα；
背景信息：
Expression of REG3B was sufficient to inhibit cytokine-induced activation of STAT3 in IECs. The human REG3beta protein, the functional counterpart of mouse REG3B, inhibited STAT3 activity in human 293T cells, and its expression level in colorectal tumors correlated inversely with pSTAT3 level and survival times of patients. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. This pathway might be targeted in patients with colitis to reduce carcinogenesis.
