靶标：
Pikfyve
产品别名：
5230400C17Rik； Pip5k； Pip5k3； Pipk5k3； PipkIII； p235； Pikfyve； phosphoinositide kinase, FYVE type zinc finger containing； phosphoinositide kinase, FYVE type zinc finger containing； 1-phosphatidylinositol 3-phosphate 5-kinase； FYVE finger-containing phosphoinositide kinase； PIPkin-III； PtdIns(4)P-5-kinase； phosphatidylinositol 3-phosphate 5-kinase type III； phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III； phosphatidylinositol-4-phosphate 5-kinase, type III； phosphoinositide kinase, FYVE finger containing； serine-protein kinase PIKFYVE； type III PIP kinase； 含FYVE指磷酸肌醇激酶(PIKFYVE)； 磷脂酰肌醇3磷酸激酶5Ⅲ型；
背景信息：
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKf
