靶标：
Shc3
产品别名：
N-Shc； Rai； ShcC； Shc3； src homology 2 domain-containing transforming protein C3； src homology 2 domain-containing transforming protein C3； SHC-transforming protein 3； SH2 domain protein C3； SHC-transforming protein C； neuronal Shc； SH2结构域蛋白C3； SHC-转化蛋白3(SHC3)；
背景信息：
function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,PTM:Tyrosine phosphorylated.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.,tissue specificity:Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.,
