靶标：
PUF60
产品别名：
FIR； RoBPI； SIAHBP1； VRJS； PUF60； poly(U) binding splicing factor 60； poly(U) binding splicing factor 60； poly(U)-binding-splicing factor PUF60； FBP interacting repressor； FUSE-binding protein-interacting repressor； Ro ribonucleoprotein-binding protein 1； Siah binding protein 1； poly(U) binding splicing factor 60KDa； pyrimidine tract binding splicing factor； 60kDa多聚U结合剪接因子(PUF60)；
背景信息：
This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
