靶标：
LMTK2
产品别名：
AATYK2； BREK； KPI-2； KPI2； LMR2； PPP1R100； cprk； hBREK； LMTK2； lemur tyrosine kinase 2； lemur tyrosine kinase 2； serine/threonine-protein kinase LMTK2； CDK5/p35-regulated kinase； apoptosis-associated tyrosine kinase 2； brain-enriched kinase； cyclin-dependent kinase 5/p35-regulated kinase； kinase/phosphatase/inhibitor 2； protein phosphatase 1, regulatory subunit 100； serine/threonine-protein kinase KPI-2； 丝氨酸/苏氨酸蛋白激酶KPI2；
背景信息：
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009],
