靶标：
ICOSLG
产品别名：
B7-H2； B7H2； B7RP-1； B7RP1； B7h； CD275； GL50； ICOS-L； ICOSL； LICOS； ICOSLG； inducible T cell costimulator ligand； inducible T cell costimulator ligand； ICOS ligand； B7 homolog 2； B7 homologue 2； B7-like protein Gl50； B7-related protein 1； transmembrane protein B7-H2 ICOS ligand； T-细胞可诱导共刺激分子配体(ICOSLG)； 诱导协同刺激分子配体CD275；
背景信息：
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.
