靶标：
ARHGEF18
产品别名：
P114-RhoGEF； RP78； SA-RhoGEF； p114RhoGEF； ARHGEF18； Rho/Rac guanine nucleotide exchange factor 18； Rho/Rac guanine nucleotide exchange factor 18； rho guanine nucleotide exchange factor 18； 114 kDa Rho-specific guanine nucleotide exchange factor； Rho-specific guanine nucleotide exchange factor p114； Rho/Rac guanine nucleotide exchange factor (GEF) 18； septin-associated RhoGEF； G蛋白偶联受体ARHGEF18；
背景信息：
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). p114RgoGEF cts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. It may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS), but does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.
