靶标：
EXOSC2
产品别名：
RRP4； Rrp4p； SHRF； hRrp4p； p7； EXOSC2； exosome component 2； exosome component 2； exosome complex component RRP4； exosome complex exonuclease RRP4； homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4)； homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease； ribosomal RNA-processing protein 4； RRP4蛋白； 外切酶体成分2(EXOSC2)；
背景信息：
Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snoRNA and snRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. EXOSC2 is a non-catalytic component of the RNA exosome complex that has 3'->5' exoribonuclease activity and involves in a multitude of cellular RNA processing and degradation events.
