靶标:
ATP1B4
产品别名:
ATP1B4; ATPase Na+/K+ transporting family member beta 4; ATPase Na+/K+ transporting family member beta 4; protein ATP1B4; ATPase, Na+/K+ transporting, beta 4 polypeptide; BetaM; Na,K-ATPase beta m-subunit; X,K-ATPase beta-m subunit; x/potassium-transporting ATPase subunit beta-m; 钠/钾离子转运ATP酶β4肽(ATP1b4);
背景信息:
This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene.