靶标：
SMUG1
产品别名：
FDG； HMUDG； UNG3； SMUG1； single-strand-selective monofunctional uracil-DNA glycosylase 1； single-strand-selective monofunctional uracil-DNA glycosylase 1； single-strand selective monofunctional uracil DNA glycosylase； SMUG1蛋白； 单链选择性单功能尿嘧啶DNA糖基化酶1(SMUG1)；
背景信息：
The base excision repair (BER) pathway corrects small base lesions in DNA due to oxidation, deamination, or misincorporation of dUTP instead of dTTP during DNA replication. These bases are removed by DNA glycosylases, resulting in abasic sites that are then repaired through short- or long-patch BER (1,2).
Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) removes uracil and oxidized pyrimidines from DNA. SMUG1 expression is important for genome stability, and high expression of SMUG1 is correlated with favorable prognosis in human cancer (3). Knockdown or knockout of SMUG1 results in decreased proliferation, as well as increased DNA damage and apoptosis (4).
