靶标:
LDOC1
产品别名:
BCUR1; Mar7; Mart7; RTL7; SIRH7; LDOC1; LDOC1 regulator of NFKB signaling; LDOC1 regulator of NFKB signaling; protein LDOC1; Sushi-Ichi retrotransposon homolog 7; breast cancer, up-regulated 1; leucine zipper down-regulated in cancer 1; leucine zipper downregulated in cancer; leucine zipper protein down-regulated in cancer cells; mammalian retrotransposon-derived 7; retrotransposon Gag like 7; 癌亮氨酸拉链下调节因子1(LDOC1); 癌症亮氨酸拉链下调因子1;
背景信息:
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008],