靶标：
Aloxe3
产品别名：
e-LOX-3； eLOX-3； Aloxe3； arachidonate lipoxygenase 3； arachidonate lipoxygenase 3； hydroperoxide isomerase ALOXE3； epidermal LOX-3； epidermis-type lipoxygenase 3； hydroperoxy dehydratase ALOXE3； hydroperoxy icosatetraenoate dehydratase； hydroperoxy icosatetraenoate isomerase； 花生四烯酸脂加氧酶3(ALOXE3)； 过氧化氢异构酶ALOXE3；
背景信息：
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.
