靶标：
SUN2
产品别名：
UNC84B； rab5IP； SUN2； Sad1 and UNC84 domain containing 2； Sad1 and UNC84 domain containing 2； SUN domain-containing protein 2； Sad1 unc-84 domain protein 2； nuclear envelope protein； protein unc-84 homolog B； rab5-interacting protein； sad1/unc-84 protein-like 2； unc-84 homolog B；
背景信息：
SUN1 and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity.
