靶标：
TNFAIP8
产品别名：
GG2-1； MDC-3.13； NDED； SCC-S2； SCCS2； TNFAIP8； TNF alpha induced protein 8； TNF alpha induced protein 8； tumor necrosis factor alpha-induced protein 8； NF-kappa-B-inducible DED-containing protein； TNF-induced protein GG2-1； head and neck tumor and metastasis-related protein； tumor necrosis factor, alpha induced protein 8； 肿瘤坏死因子α诱导蛋白8；
背景信息：
developmental stage:Expressed at high levels in the fetal liver, lung and kidney.,function:Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.,induction:By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.,similarity:Belongs to the TNFAIP8 family.,tissue specificity:Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.,
