靶标:
BRMS1
产品别名:
BRMS1; BRMS1 transcriptional repressor and anoikis regulator; BRMS1 transcriptional repressor and anoikis regulator; breast cancer metastasis-suppressor 1; breast cancer metastasis suppressor 1; 乳腺癌转移抑制基因1;
背景信息:
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],