靶标:
FBXL3
产品别名:
FBL3; FBL3A; FBXL3A; IDDSFAS; FBXL3; F-box and leucine rich repeat protein 3; F-box and leucine rich repeat protein 3; F-box/LRR-repeat protein 3; F-box and leucine-rich repeat protein 3A; F-box protein Fbl3a; F-box/LRR-repeat protein 3A; F-框亮氨酸丰富重复蛋白3(FBXL3); FBXL3蛋白;
背景信息:
Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.