靶标:
C5AR2
产品别名:
C5L2; GPF77; GPR77; C5AR2; complement C5a receptor 2; complement C5a receptor 2; C5a anaphylatoxin chemotactic receptor 2; C5a anaphylatoxin chemotactic receptor C5L2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; complement component 5a receptor 2; G蛋白偶联受体77; G蛋白偶联受体C5L2蛋白;
背景信息:
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012],