靶标：
IFT57
产品别名：
CG8853； CHE-13； Che-13； Dmel\CG8853； Hippi； IFT55； che-13； IFT57； Intraflagellar transport 57； Intraflagellar transport 57； intraflagellar transport 57； CG8853-PA； Che-13 ortholog； IFT57-PA； hippi； 舞蹈症相关相互作用蛋白1/雌激素相关受体样蛋白1；
背景信息：
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
