靶标：
NANS
产品别名：
CG5232； DmSAS； Dmel\CG5232； Nans； Neu5Ac； SAS； Sas； sas； NANS； N-acetylneuraminic acid synthase； N-acetylneuraminic acid synthase； N-acetylneuraminic acid synthase； CG5232-PA； N-acetylneuraminic acid phosphate synthase； NANS-PA； Neu5Ac synthase； sialic acid phosphate synthase； sialic acid synthase； N-乙酰神经氨酰酸合酶(NANS)； N-乙酰神经氨酸合酶；
背景信息：
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.
