靶标：
PLEKHO1
产品别名：
CKIP-1； CKIP1； JBP； OC120； PLEKHO1； pleckstrin homology domain containing O1； pleckstrin homology domain containing O1； pleckstrin homology domain-containing family O member 1； C-Jun-binding protein； CK2 interacting protein 1; HQ0024c protein； CK2-interacting protein 1； PH domain-containing family O member 1； casein kinase 2-interacting protein 1； osteoclast maturation-associated gene 120 protein； 酪蛋白激酶2相互作用蛋白1；
背景信息：
Pleckstrin homology domain-containing family O member 1?is a?protein?that in humans is encoded by thePLEKHO1?gene. Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival.
