靶标:
GP6
产品别名:
BDPLT11; GPIV; GPVI; GP6; glycoprotein VI platelet; glycoprotein VI platelet; platelet glycoprotein VI; glycoprotein 6; platelet collagen receptor; 糖蛋白VI/六糖蛋白; 膜糖蛋白Ⅵ(GP6);
背景信息:
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],