靶标:
MZB1
产品别名:
MEDA-7; PACAP; pERp1; MZB1; marginal zone B and B1 cell specific protein; marginal zone B and B1 cell specific protein; marginal zone B- and B1-cell-specific protein; HSPC190; caspase-2 binding protein; mesenteric estrogen-dependent adipose 7; mesenteric oestrogen-dependent adipose gene- 7; plasma cell-induced ER protein 1; plasma cell-induced resident ER protein; plasma cell-induced resident endoplasmic reticulum protein; proapoptotic caspase adapter protein; proapoptotic caspase adaptor protein;
背景信息:
边缘区 B 细胞与 B1 细胞特异性蛋白 (MZB1) 是一种由边缘区 B 细胞及在浆细胞分化期间表达的 ER 驻留性伴侣蛋白 (1,2)。MZB1 具有辅助浆细胞正确折叠、组装和分泌成熟 IgM 的氧化还原酶活性 (1,3) 。研究已表明,MZB1 表达丢失损害抗体分泌和体液免疫应答 (4)。