靶标:
DACT1
产品别名:
DAPPER; DAPPER1; DPR1; FRODO; HDPR1; TBS2; THYEX3; DACT1; dishevelled binding antagonist of beta catenin 1; dishevelled binding antagonist of beta catenin 1; dapper homolog 1; dapper antagonist of catenin 1; dapper, antagonist of beta-catenin, homolog 1; hepatocellular carcinoma novel gene 3 protein; heptacellular carcinoma novel gene 3; 肝癌新基因3蛋白;
背景信息:
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene.