靶标:
UCHL5
产品别名:
CGI-70; INO80R; UCH-L5; UCH37; UCHL5; ubiquitin C-terminal hydrolase L5; ubiquitin C-terminal hydrolase L5; ubiquitin carboxyl-terminal hydrolase isozyme L5; INO80 complex subunit R; ubiquitin C-terminal hydrolase UCH37; ubiquitin carboxyl-terminal esterase L5; ubiquitin carboxyl-terminal hydrolase L5; ubiquitin thioesterase L5; 泛素羧基端酯酶L5(UCHL5);
背景信息:
Uch37 is one of the deubiquitinating enzymes of the human 26S proteasome, belongs to the Ub C-terminal hydrolases. Uch37 was found to bind both Adrm1 and S5a subunits of the 26S proteasome. Uch37 likely contributes to the Ub chain trimming activity of the 26S proteasome that shortens a polyUb chain from the distal end of the chain.