靶标：
RNF111
产品别名：
ARK； hRNF111； RNF111； ring finger protein 111； ring finger protein 111； E3 ubiquitin-protein ligase Arkadia； Arkadia； RING-type E3 ubiquitin transferase Arkadia； 环指蛋白111；
背景信息：
ring finger protein 111(RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],
