靶标：
NDE1
产品别名：
HOM-TES-87； LIS4； MHAC； NDE； NUDE； NUDE1； NDE1； nudE neurodevelopment protein 1； nudE neurodevelopment protein 1； nuclear distribution protein nudE homolog 1； LIS1-interacting protein NUDE1, rat homolog； epididymis secretory sperm binding protein； nudE nuclear distribution E homolog 1； nudE nuclear distribution gene E homolog 1； 核分布基因E同源蛋白1；
背景信息：
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012],
