靶标:
ASPN
产品别名:
OS3; PLAP-1; PLAP1; SLRR1C; ASPN; asporin; asporin; asporin; asporin (LRR class 1); asporin proteoglycan; periodontal ligament associated protein 1; small leucine-rich protein 1C; 无孢蛋白(ASPN);
背景信息:
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.