靶标:
UACA
产品别名:
NUCLING; UACA; uveal autoantigen with coiled-coil domains and ankyrin repeats; uveal autoantigen with coiled-coil domains and ankyrin repeats; uveal autoantigen with coiled-coil domains and ankyrin repeats; nuclear membrane binding protein; 卷曲域锚蛋白重复序列葡萄膜自身抗原(UACA); 葡萄膜自身抗原Uaca;
背景信息:
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).