DIP13β抗体

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DIP13β抗体

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Anti-APPL2
Anti-adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 Antibody

靶标：

APPL2

产品别名：

DIP13B； APPL2； adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2； adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2； DCC-interacting protein 13-beta； DIP13 beta； adapter protein containing PH domain, PTB domain and leucine zipper motif 2； adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2； DIP13β；

背景信息：

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.

宿主：Rbt
类型：Pab
同种型:IgG
应用：WB
纯化方式：亲和纯化
偶联物：Unconjugated
性状：液体
存储溶液：参阅说明书
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存：经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。