靶标：
PLEKHG6
产品别名：
MyoGEF； PLEKHG6； pleckstrin homology and RhoGEF domain containing G6； pleckstrin homology and RhoGEF domain containing G6； pleckstrin homology domain-containing family G member 6； PH domain-containing family G member 6； myosin II interacting GEF； myosin interacting guanine nucleotide exchange factor； pleckstrin homology domain containing, family G (with RhoGef domain) member 6； 肌球蛋白相互作用G蛋白交换因子；
背景信息：
PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
