靶标:
TRIM62
产品别名:
DEAR1; TRIM62; tripartite motif containing 62; tripartite motif containing 62; E3 ubiquitin-protein ligase TRIM62; RING-type E3 ubiquitin transferase TRIM62; ductal epithelium-associated RING Chromosome 1; tripartite motif-containing protein 62; TRIM62蛋白;
背景信息:
E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways. E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.