靶标：
NUDT15
产品别名：
MTH2； NUDT15D； NUDT15； nudix hydrolase 15； nudix hydrolase 15； nucleotide triphosphate diphosphatase NUDT15； 8-oxo-dGTPase NUDT15； mutT homolog 2； nucleoside diphosphate-linked to another moiety X hydrolase 15； nudix (nucleoside diphosphate linked moiety X)-type motif 15； probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15； probable 8-oxo-dGTP diphosphatase NUDT15； NUDT15蛋白；
背景信息：
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.
