靶标:
MACROH2A2
产品别名:
H2AFY2; MACROH2A2; macroH2A.2 histone; macroH2A.2 histone; core histone macro-H2A.2; H2A histone family member Y2; core histone macroH2A2.2; histone macroH2A2; mH2A2; 异型组蛋白H2A.2;
背景信息:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Oct 2015],