靶标:
PRPF40A
产品别名:
FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10; HYPA; NY-REN-6; Prp40; PRPF40A; pre-mRNA processing factor 40 homolog A; pre-mRNA processing factor 40 homolog A; pre-mRNA-processing factor 40 homolog A; Fas-ligand associated factor 1; Huntingtin-interacting protein A; NY-REN-6 antigen; PRP40 pre-mRNA processing factor 40 homolog A; fas ligand-associated factor 1; formin binding protein 3; formin-binding protein 11; huntingtin yeast partner A; huntingtin-interacting protein 10; renal carcinoma antigen NY-REN-6; 甲精结合蛋白3;
背景信息:
domain:The WW domains are essential for localization to nuclear speckles.,function:Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). May be involved in pre-mRNA splicing.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 409.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the PRPF40 family.,similarity:Contains 2 WW domains.,similarity:Contains 5 FF domains.,subunit:Interacts with the N-terminus of HTT. Interacts with the phosphorylated carboxyterminal domain of POLR2A. Interacts with SF1, SRPK1 CARD8, ATBF1 and MECP2 (By similarity). Interacts through the WW domains with formin proline-rich regions and with WASL/N-WASP.,tissue specificity:Widely expressed.,