靶标：
ERO1B
产品别名：
ERO1LB； Ero1beta； ERO1B； endoplasmic reticulum oxidoreductase 1 beta； endoplasmic reticulum oxidoreductase 1 beta； ERO1-like protein beta； ERO1-L-beta； ERO1-like beta； endoplasmic oxidoreductin-1-like protein B； endoplasmic reticulum oxidoreductase beta； endoplasmic reticulum oxidoreductin-1-like protein B； oxidoreductin-1-L-beta； Ero1-Lβ蛋白；
背景信息：
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate, as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.
