靶标:
ANKS1B
产品别名:
AIDA; AIDA-1; ANKS2; EB-1; EB1; cajalin-2; ANKS1B; ankyrin repeat and sterile alpha motif domain containing 1B; ankyrin repeat and sterile alpha motif domain containing 1B; ankyrin repeat and sterile alpha motif domain-containing protein 1B; E2a-Pbx1-associated protein; amyloid-beta precursor protein intracellular domain associated protein 1; cajalin 2; β淀粉样蛋白胞内结构域相关蛋白1;
背景信息:
This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene.