靶标:
SENP7
产品别名:
SENP7; SUMO specific peptidase 7; SUMO specific peptidase 7; sentrin-specific protease 7; SUMO-1-specific protease 2; SUMO1/sentrin specific peptidase 7; sentrin/SUMO-specific protease SENP7; 泛素特异性蛋白酶SENP7;
背景信息:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009],