靶标：
ELAC2
产品别名：
COXPD17； ELC2； HPC2； ELAC2； elaC ribonuclease Z 2； elaC ribonuclease Z 2； zinc phosphodiesterase ELAC protein 2； RNase Z 2； elaC homolog 2； elaC homolog protein 2； elaC-like protein 2； heredity prostate cancer protein 2； putative prostate cancer susceptibility protein HPC2/ELAC2； ribonuclease Z 2； tRNA 3 endonuclease 2； tRNase Z (long form)； tRNase Z 2； 遗传性前列腺癌蛋白2；
背景信息：
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
