靶标：
PDIA2
产品别名：
PDA2； PDI； PDIP； PDIR； PDIA2； protein disulfide isomerase family A member 2； protein disulfide isomerase family A member 2； protein disulfide-isomerase A2； Rho GDP dissociation inhibitor gamma； pancreas-specific protein disulfide isomerase； pancreatic protein disulfide isomerase； protein disulfide isomerase, pancreatic； protein disulfide isomerase-associated 2； 蛋白质二硫键异构酶；
背景信息：
Protein disulfide isomerase family A member 2 is a protein that in humans is encoded by the PDIA2 gene. This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels.
