靶标：
RMND5A
产品别名：
CTLH； GID2； GID2A； RMD5； p44CTLH； RMND5A； required for meiotic nuclear division 5 homolog A； required for meiotic nuclear division 5 homolog A； E3 ubiquitin-protein transferase RMND5A； 44-kD protein coding for CTLH motif； C-terminal to LisH motif, 44 kDa； GID complex subunit 2 homolog A； protein RMD5 homolog A；
背景信息：
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.
