靶标：
Alkbh8
产品别名：
4930562C03Rik； 8030431D03Rik； 9430088N01Rik； Abh8； Alkbh8； alkB homolog 8, tRNA methyltransferase； alkB homolog 8, tRNA methyltransferase； alkylated DNA repair protein alkB homolog 8； S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8； alkB, alkylation repair homolog 8； probable alpha-ketoglutarate-dependent dioxygenase ABH8； tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8； AlkB同源蛋白8；
背景信息：
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg and tRNA(Glu, and does not bind tRNA(Lys(PubMed:20308323. Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly. Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
