靶标：
Nsmce2
产品别名：
1110014D18Rik； AI661537； Nsmce2； NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase； NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase； E3 SUMO-protein ligase NSE2； E3 SUMO-protein transferase NSE2； MMS21 homolog； non-SMC element 2 homolog (MMS21, S. cerevisiae)； non-structural maintenance of chromosomes element 2 homolog； E3连接酶MMS21蛋白；
背景信息：
NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
