靶标：
Rnf166
产品别名：
1110031E24Rik； AW555115； Zfp313l； Rnf166； ring finger protein 166； ring finger protein 166； E3 ubiquitin-protein ligase RNF166； RING-type E3 ubiquitin transferase RNF166； zinc finger protein 313; zinc finger protein 228； 环指蛋白166；
背景信息：
E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Plays also a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication.
