靶标:
Abraxas1
产品别名:
3830405G04Rik; 5630400M01Rik; AI506069; AL024423; AV118690; Ccdc98; Fam175a; Abraxas1; BRCA1 A complex subunit; BRCA1 A complex subunit; BRCA1-A complex subunit Abraxas 1; coiled-coil domain containing 98; coiled-coil domain-containing protein 98; family with sequence similarity 175, member A; 卷曲螺旋结构域蛋白98;
背景信息:
This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance, DNA repair, and cell cycle checkpoint control. Pseudogenes of this gene are found on chromosomes 3 and 8. Alternative splicing results in multiple transcript variants.