靶标：
Glyr1
产品别名：
2810419J22Rik； 3930401K13Rik； AW545332； NDF； Npac； Glyr1； glyoxylate reductase 1 homolog (Arabidopsis)； glyoxylate reductase 1 homolog (Arabidopsis)； putative oxidoreductase GLYR1； cytokine-like nuclear factor n-pac； nuclear protein NP60； 氧化还原酶GlyR1/核蛋白60；
背景信息：
Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Facilitates Pol II transcription through nucleosomes. Binds DNA (in vitro. Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3. Promotes KDM1B demethylase activity. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac by EP300. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Putative oxidoreductase.
