靶标:
Nsun6
产品别名:
4933403D21Rik; 4933414E04Rik; NOPD1; Nsun6; NOL1/NOP2/Sun domain family member 6; NOL1/NOP2/Sun domain family member 6; tRNA (cytosine(72)-C(5))-methyltransferase NSUN6; NOL1/NOP2/Sun domain family 6; putative methyltransferase NSUN6; NSUN6蛋白;
背景信息:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr(TGT and tRNA(Cys(GCA. In vitro also methylates tRNA(Thr(AGT. Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70 in the tRNA substrates.