靶标：
Col25a1
产品别名：
2700062B08Rik； CLAC-P； Col25a1； collagen, type XXV, alpha 1； collagen, type XXV, alpha 1； collagen alpha-1(XXV) chain； collagen-like Alzheimer amyloid plaque component； procollagen, type XXV, alpha 1； 阿尔茨海默病淀粉样蛋白相关胶原蛋白；
背景信息：
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
